In its ongoing effort to maintain the highest quality health care standards, Saint Anthony Hospital implemented a comprehensive Antimicrobial Stewardship Program. This program won the Illinois Health and Hospital Association (IHA) Innovation: Partners in Progress Award for the second consecutive year. This year, Saint Anthony is being recognized for reducing the unnecessary use of antibiotics and is one of only two award recipients. Nationally regulatory agencies, including the Centers for Disease Control and Prevention, and The Joint Commission have made reduction of antimicrobial use a top priority when surveying health care institutions across the country. Prior to starting the training program, only one in four pharmacists felt comfortable with antibiotics and infectious syndromes. However, after just three months, all pharmacists felt comfortable working with evidence-based guidelines for infectious syndromes. Stewardship recommendations were given in over 53 percent of all antibiotics consumed. Ultimately, this led to a total decrease in antibiotic use, increase use of oral alternatives, and reduction in unnecessary costs. A panel of judges consisting of statewide and nationally recognized health care quality experts evaluated submissions from hospitals and health systems from across the state based on their improvement impact and the applicant’s willingness to help bring innovations that can lead to better outcomes both locally and statewide.